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By F. Sherwood. Taylor

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In the test animals more often than in the controls and to a sharper degree, we observed disturbance in the function of excitability of the myocardium (paroxysmal ventricular tachycardia, idioventricular rhythm, group ven­ tricular extrasystoles). As Table 1 shows, intravenous injection of adrenaline after 12 months burdening produced heavier inhibition in the test rabbits (first and second groups) (by46-4+5-1 percent for 1 piCi/kgand 51-7 + 4-7 per cent in those receiving 10 fjiCi/kg) as compared with the controls for which the figures were 32-2 + 3-1 per cent for the biological controls and 30-8 + 3 per cent for those receiving stable zinc).

Thanks to the reflexes from the pressoreceptors on the vagus centre administration of adrenaline causes thinning out of the rhythm of cardiac activity. Excitation of the nuclei of the vagus nerve also appears as the result of the direct action of adrenaline. 9 1959, 1961; Saitanov, 1967; and others) have used administra­ tion of adrenaline to elucidate the functional state of the mechanisms regulating cardiac activity on exposure of the body to ionizing radiations. Some authors indicate that preliminary exposure to ionizing radiations lowers the threshold of sensitivity to adrenaline and relate this to changes in the medullary layer of the suprarenals observed for low doses of internal radiation (Durmish'yan, Azhipa, Godin, and others, 1961).

I FIG. 2. Electrocardiograms of rabbits in the second standard lead before (left segment of ECG) and after inhalation of vapours of 10 per cent solution of ammonia (right segment of ECG). (a) ECG of rabbit No. 57, biological control in twelfth month of observation; (b) ECG of rabbit No. 26 receiving stable zinc isotope for 12 months; (c) ECG of rabbit No. 29 in twelfth month of burdening (10 ptCi/kg) 54 The Toxicology of Radioactive Substances Thus, our experimental findings show that in the early stages of chronic exposure to low doses of radiozinc it is possible to observe phasic (at 4-5 months and 12 months of burdening with 10 (jiCi/kg) changes in the sensitivity of the adrenoreactive systems of the myocardium and neuroreflex regulation of cardiac activity brought out by administration of pharmacological agents.

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