Download Acute Toxicology Testing by Shayne C. Gad PDF

By Shayne C. Gad

Acute toxicology checking out offers the 1st defensive position opposed to most likely harmful chemical substances. This e-book is an entire and functional consultant to undertaking and analyzing all regulatory required and normal acute toxicity assessments. It offers precise protocols for all the universal try designs and studies their improvement and goals. Acute Toxicology trying out, moment Edition will curiosity not just staff within the pharmaceutical undefined, but additionally researchers and scholars in toxicology and public health.

Key Features
* Over a hundred tables summarizing and analyzing results
* whole insurance of all significant attempt designs and their barriers and advantages
* present prestige of different attempt designs and versions

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Example text

The test substance patch is placed on skin site 1 and secured. a. 5 g. b. , the gauze patch designated for the test sample is secured to the appropriate skin site with one of four strips of tape at the most central position of the animal. 5 ml is carefully poured from a glycine weighing paper onto the gauze patch, which is held in a horizontal (level) position with the other hand. The patch containing the test sample is then carefully placed into position onto the skin by raising the remaining three edges dorsally until they are completely secured with tape.

Pharmacol. 31,481-590. Organization for Economic Cooperation and Development (OECD) (1992). OECD guidelines for testing of chemicals, Section 404, Acute Dermal Irritation/Corrosion, adopted July 17, 1992, Paris. , Maibach, H. , and Burkhalter, A. (1985). Mechanisms of chemically induced skin irritation. Toxicol. Appl. Pharmacol. 81,476-490. , Maibach, H. , and Akers, W. A. (1972). A comparison of rabbit and human skin response to certain irritants. Toxicol. Appl. Pharmacol. 21,369-382. , and Ferguson, T.

King, T. , Nelson, R. , and Gad, S. C. (1995). Information sources: Building and maintaining data files. In Safety Assessment for Pharmaceuticals (S. C. ). Van Nostrand Reinhold, New York. Lu, F. C. (1985). Basic Toxicology, pp. 68-95. Hemisphere, New York. Page, N. P. (1986). International harmonization of toxicity testing. In Safety Evaluation of Drugs and Chemicals (W. E. ), pp. 455-467. Hemisphere, New York. Russell, W. M. , and Burch, R. L. (1959). The Principles of Humane Experimental Technique.

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