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By Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)

Adjuvant remedy is run sooner than or as stick with as much as surgeries for breast melanoma. confirmed good fortune in utilizing clinical remedies making an allowance for breast preserving tactics or decreasing hazard of incidence. even though there was a lot growth in the direction of a healing, together with the creation of latest certain remedies, metastasizing melanoma continues to be hugely incurable.

"The adjuvant remedy of breast melanoma has turn into average of care. A spectrum of biologic and prognostic components are thought of prior to a healing method is applied. during this textual content major investigators within the box speak about present administration and important investigative issues."

Steven T. Rosen, M.D.
Series Editor

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Extra info for Adjuvant Therapy for Breast Cancer

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50. Paik S, Bryant J, Tan-Chiu E, et al. HER2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B15. J Natl Cancer Inst. 2000;92:1991–8. Prognostic and Predictive Factors 29 51. Di Leo A, Larsimont D, Gancberg D, et al. HER-2 and topoisomerase as predictive markers in a population of node positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. Ann Oncol. 2001;12:1081–9. 52.

2004;25:1473–9. 30 L. Biganzoli 68. Mueller RE, Parkes RK, Andrulis I, et al. Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples. Genes Chromosomes Cancer. 2004;39:288–97. 69. Callagy G, Pharoah P, Chin SF, et al. Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays. J Pathol. 2005;205:388–96. 70. Di Leo A, Chan S, Paesmans M, et al. HER-2/neu as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel.

13. Sotiriou C, Wirapati P, Loi S, et al. Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis. Natl Cancer Inst. 2006;98:262–72. 14. Ross JS, Fletcher JA, Linette GP, et al. The Her-2/neu gene and protein in breast cancer 2003: Biomarker and target of therapy. Oncologist. 2003;8:307–25, 2003 15. Pinder SE, Ellis IO, Galea M, et al. Pathological prognostic factors in breast cancer. III. Vascular invasion: Relationship with recurrence and survival in a large study with longterm follow-up.

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