By Kurt W. Kohn (auth.), Professor John W. Corcoran Ph.D., Professor Fred E. Hahn Ph.D., J. F. Snell, K. L. Arora (eds.)
This quantity is the 3rd within the sequence dedicated to Antibiotics initiated by way of Springer Verlag in 1967. the 1st volumes have been dedicated to the Mode of motion of Antibiotics and Biogenesis, respectively and have been got graciously. throughout the intervening years those works were used usually by way of examine staff and scholars alike and feature been quoted commonly. even if a couple of different very good treatises on antibiotics have seemed, the Springer sequence has set a regular for thoroughness and caliber that meets the necessity of the clinical group. it truly is by contrast history that the current Editors set in regards to the instruction of a 3rd quantity within the sequence on Antibiotics. because the visual appeal of quantity I, additionally facing Mechanism of motion, large strides were made within the intensity and breadth of our wisdom of molecular biology, microbial chemistry and molecular pharmacology and in their direct software to experiences at the mode of motion of gear. the sphere of molecular biology itself was once in its relative infancy through the previous decade and the original position performed through many anti biotics within the improvement of our knowing of nucleic acid synthesis and serve as and its courting to protein synthesis and mobilephone body structure has led quickly to a truly particular, realizing of the way a lot of those similar antibiotics inhibit vulnerable cells.
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Additional resources for Mechanism of Action of Antimicrobial and Antitumor Agents
A. LECHEVALIER, and M. SOLOTOROVSKY: Antitumor activity of a substance produced by a strain of Helminthosporium. Antibiot. & Chemotherapy 12, 310 (1962). J. GUARINO: Studies on the inhibition of Bacillus subtilis growth by cordycepin. Biochim. Biophys. Acta 80, 632 (l964a). J. GUARINO: The inhibition of purine biosynthesis de nova in Bacillus subtilis by cordycepin. Biochim. Biophys. Acta 80, 640 (1964 b). SHIGEURA, H. , and G. E. BOXER: Incorporation of 3' -deoxyadenosine-Y-triphosphate into RNA by RNA polymerase from Micrococcus lysodeikticus.
32,1966 (1972). , H. NISHIWAKI, K. KAWASHIMA, T. UETANI, M. HIRANO, M. MIURA, and K. YAMADA: Lack of immunosuppressive effect of bleomycin on the primary response of mice to sheep red blood cells. Gann 62, 267 (1971). , T. TAKITA, K. MAEDA, H. UMEZAWA, and S. UMEZAWA: The chemistry of bleomycin. VIII. The structure of the sugar moiety of bleomycin A 2. J. Antibiotics (Tokyo) 25, 752 (1972). , M. MIYAKI, and J. KURODA: Studies on bleomycin-DNA. Report at the Annual Meeting of the Japan Cancer Society, at Nagoya, November, 1972.
TANAKA, and H. UMEZAWA: Effect of bleomycin A2 on deoxyribonuclease, DNA polymerase and ligase reactions. J. Antibiotics (Tokyo) 24, 178 (1971). , N. TANAKA, and H. UMEZAWA: Effects of several tumor-inhibitory antibiotics on immunological responses. J. Antibiotics (Tokyo) 22, 315 (1969). , Y. MURAOKA, T. TAKITA, K. MAEDA, and H. UMEZAWA: Chemistry of bleomycin. VII. Synthesis of p-amino-p-(4-amino-6-carboxy-5-methylpyrimidin-2yl)-propionic acid, an amine component of bleomycin. J. Antibiotics (Tokyo) 25, 625 (1972).